Traditional treatments for gangrene and refractory skin ulcers involve using pedicle flaps or free flaps to close the wound after debridement. However, this method makes it difficult to reconstruct the original tissue, leaving scars and tissue defects without true regeneration.

Aiming to develop scaffold materials that promote natural wound healing, considering quality of life (QOL), without the need for transplantation or suturing, just by placing them on the tissue. Focusing on restoring local blood flow and successfully reconstructing vascular niches, clinical applications in plastic surgery, dental and oral surgery, and dermatology are being considered.

From an embryological standpoint, creating bioink that expresses cell-targeting peptides on scaffold materials using a 3D bioprinter and attempting to design tissue-specific vascular structures. This approach promotes natural layered tissue regeneration and scarless wound healing, avoiding hypertrophic scars and keloids.

The goal is to create scaffolds at the cell processing center (CPC) of the Regenerative Medicine Department at Shiga University of Medical Science Hospital and conduct clinical trials in facilities with CPC environments.